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    Thursday, July 25, 2002

    Antibiotic Resistance II: The New England Journal of Medicine has two studies this week that highlight the problem of antibiotic resistance and the overuse of antibiotics. For several years now, it has been the standard of care to treat women with a type of bacteria called Group B streptococci in their vaginas with antibiotics during labor. The bacteria can cause deadly infections in newborns. There were two ways to go about this: you could test everyone for the bacteria and give them anitbiotics during labor if they were positive, or you could not screen and give antibiotics only to those women who would be at higher risk of passing the bacteria to their babies: those with preterm labor, those whose water broke early, or those who had a fever. In our litiginous society, guess which approach is used most? You got it. Screen and treat everyone. The two studies show that while screening everyone reduces the rate of Group B strep infections in babies, it also increases the rate of infections by another type of bacteria, E. coli.

    Both E. coli and Group B strep are natural residents in the vagina. Not every newborn is threatened by them. Yet, it can be difficult to predict which baby will pick up the infection. A direct comparison of screening everyone with taking a risk-based approach found fewer babies got Group B strep if everyone was screened and treated. But, at the same time, another study that looked at infections in low birth weight babies found that the same number of babies get sick, but more of them have infections caused by antibiotic resistant E. coli. This was especially true if their mothers received antibiotics for Group B strep during their delivery. The study in low birth weight infants is particularly relevant because these infants are very vulnerable to infection. Any trends in types of infection and in their resistance to antibiotics would likely show up in them before it shows up in the normal newborn population. This is a warning to us all. We need to be more careful with antibiotics, even though it may mean we will miss the chance to prevent a few group B step infections.

    The neonatal nursery at the hospital where I practice has made the prevention of Group B strep a priority. Not only do all women get screened and treated with antibiotics, all babies get antibiotics for at least fourty-eight hours if their mothers weren’t screened or if their mothers didn’t recieve the requisite two doses of antibiotics during labor. It’s a mandatory protocol that all doctors caring for newborns there must follow. I don’t know what effect this has had on Group B strep infections, but I know that this past weekend I treated my first case since residency of E. coli sepsis in a normal newborn. Makes me wonder.....
     

    posted by Sydney on 7/25/2002 07:19:00 AM 0 comments

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