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Saturday, August 24, 2002Severe neuropsychiatric reactions (psychosis or convulsions) in response to prophylactic doses of mefloquine have been infrequently reported (in 1 in 10,000 to 1 in 13,000 users). Milder neuropsychological adverse events (anxiety, depression, nightmares, sleep disturbances, and cognitive changes) that are disabling enough to result in drug discontinuation have been reported in 1 in 140 to 1 in 250 users. However, six randomized, double-blind trials and seven prospective comparative studies failed to find significant differences in the rates of adverse events or drug discontinuation between subjects taking mefloquine and those taking other antimalarial drugs. A rate of 1 in 10,000 to 13,000 makes it unlikely that the drug was responsible for the Fort Bragg murders. That is, unless it was fish Lariam. Then anything’s possible. posted by Sydney on 8/24/2002 07:34:00 AM 0 comments 0 Comments: |
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