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Friday, March 07, 2003Current recommendations to manage dyslipidaemia in diabetic patients are based on observational evidence and expert judgment. The heart protection study showed that simvastatin significantly reduced the risk of major vascular events for diabetic patients without coronary heart disease at any initial low density lipoprotein concentration. It remains unclear whether the benefits of statins are mediated by lowering low density lipoprotein concentrations, whether goals of treatment should be expressed as low density lipoprotein concentrations, and whether a fixed dose of statin, increasing doses of statin, or multiple drugs can be used to achieve these goals with acceptable safety. Recommendations from policymakers and experts should reflect this uncertainty. Yes, it should. Yet, the current recommendation to keep the LDL cholesterol to less than 100 in diabetics is often characterized as "practicing evidence-based medicine". It may be based on evidence, but it’s not good evidence. posted by Sydney on 3/07/2003 07:37:00 AM 0 comments 0 Comments: |
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