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Tuesday, July 22, 2003The investigators separated the natural magnolia mixture chromatographically and tested the fractions for their ability to prevent the growth of an endothelial cell line in culture. Endothelial cells make up the walls of blood vessels. They identified honokiol, a compound previously studied by Japanese researchers in herbal medicines, as the active component of the magnolia extract. Honokiol reduced the growth of endothelial cells by driving them into apoptosis, a self-destruction program activated by cells when their growth signals are disrupted. Importantly for the specificity of its anti-tumor activity, honokiol inhibited the growth of endothelial cells more than other kinds of cells. The researchers examined magnolia cones, but magnolia bark already has a history of medicinal uses. posted by Sydney on 7/22/2003 08:27:00 AM 0 comments 0 Comments: |
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