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    Monday, June 28, 2004

    Misperceptions: The study that scared women off hormone replacement therapy is being accused of fatal flaws:

    But a report in the June issue of the journal Fertility and Sterility says women recruited for the study were not representative of those taking the drug and the results were wrongly interpreted.

    Most subjects were in their 60s, some were in the early 70s and almost all had long since gone through the menopause, the authors say. Because the study was set up to test the effects of HRT on heart disease, most had heart problems when it started, the report said.

    'It's a very sad outcome from a very important study. But this was a study on aging women who very likely already had some level of cardiovascular disease when they started,' said lead author Dr. Frederick Naftolin of Yale University. 'People interpreted them as having implications for younger women, that was the real tragedy.


    The study is no longer available on-line in its entirety, only the abstract, but I seem to remember that the two groups were the same as far as age distribution goes. However, the differences in stroke and heart disease and breast cancer were so small (less than one percentage point), that it's quite possible small differences in age distribution would play a role. Why didn't these guys speak out two years ago?
     

    posted by Sydney on 6/28/2004 08:50:00 AM 0 comments

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