Cancer and Aging: New research may have found the molecular basis of cancer in aging cells:
In order to solve the cancer mystery, You's team investigated the human gene Bcl-2, which causes the arrest of growth or aging of cells, and found the Bcl-2-induced cell growth slowdown does not protect these cells from shifting to explosive cell growth.
Instead, Bcl-2 barred the DNA repair mechanism, depriving the human body of a significant tool in countering mutations, dramatically heightening the likelihood of tumors appearing.
"Up until now, scientists have suspected cells accumulate mutations when they are young and become tumors when they are old. But we have learned aged cells suffer abrupt mutations due to a lack of DNA repair," You said.
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